AIDS-related Kaposi sarcoma (KS) after failure of highly active antiretroviral therapy (HAART) in adults. Kaposi sarcoma in HIV-negative adults.
Medicince introduction including background, function, caution, etc.
Indication Pomalidomide is an anti-angiogenic which is used to treat Multiple Myeloma (cancer in plasma cells).
Side Effects Shortness of breath,Upper respiratory infections,Back pain , muscle pain
Mechanism Of Action It is an immunomodulatory agent with antineoplastic activity. It stops the proliferation and induces apoptosis of various tumour cells. In addition to this promalidomide improves T cell and natural killer (NK) cell-mediated immunity , and also prevents the production of pro-inflammatory cytokines, like TNF-alpha or IL-6, by monocytes.