Patent medicine name
Manufacturer
Specification
Price
Generic medicine name & Manufacturer
Seroflo 250mg 1 Inhaler, Cipla Ltd
Specification
Physical Form: Inhaler, Quantity: 1/box, Storage: Room Temperature(10-30°C)
Price
$10-20
Composition
Salmeterol (25mcg) + Fluticasone Propionate (250mcg)
Use
It is used in the management of asthma and chronic obstructive pulmonary disease (COPD).
Medicince introduction including background, function, caution, etc.
Indication
It is indicated in the treatment of asthma with an inhaled corticosteroid, prevention of exercise induced bronchospasm, and the maintenance of airflow obstruction and prevention of exacerbations of chronic obstructive pulmonary disease
Side Effects
Upper respiratory tract infections
throat irritation
hoarseness, voice changes, and trouble speaking
Mechanism Of Action
Beta-2 adrenoceptor stimulation causes relaxation of bronchial smooth muscle, bronchodilation, and increased airflow.
Salmeterol is hypothesized to bind to 2 sites on the beta-2 adrenoceptor.1 The saligenin moiety binds to the active site of the beta-2 adrenoceptor.The hydrophilic tail of salmeterol binds to leucine residues in the exo-site of the beta-2 adrenoceptor almost irreversibly, allowing salmeterol to persist in the active site, which is responsible for it’s long duration of action.
Another hypothesis is that the lipophilic drug diffuses into lipid bilayer of smooth muscle cells and provides a depot of drug to the cells over a longer period of time
Use in Other language
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