Patent medicine name
Casodex 50mg 28 Tablet
Manufacturer
AstraZeneca
Specification
Physical Form: Tablet, Quantity: Tablets 28 /box, Storage: Room Temperature(10-30°C)
Price
$ 25-30
Generic medicine name & Manufacturer
Calutide 50mg 10s, Cipla
Specification
Physical Form: Tablet, Quantity: 10/box, Storage: Room Temperature(10-30°C)
Price
$5-10
Composition
Bicalutamide USP 50mg
Use
Bicalutamide is used in the treatment of prostate cancer that has spread to other areas of the body. Bicalutamide is used in combination with hormone treatment. Bicalutamide works by blocking the action of male hormones in the prostate, slowing growth of the tumors.
Medicince introduction including background, function, caution, etc.
Indication
Bicalutamide is used together with a luteinizing hormone releasing hormone (LHRH) analog (eg, goserelin or leuprolide) to treat stage D2 metastatic prostate cancer (cancer that has spread) in men. Bicalutamide belongs to the group of medicines called antiandrogens. It works by blocking the effects of testosterone (a male hormone), which helps stop the growth and spread of cancer cells
Urticaria, interstitial lung disease; rarely abdominal pain, CV disorders
Mechanisam of Action
Bicalutamide competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin, thus preventing the growth of normal and malignant prostatic tissue. Absorption: Well absorbed from the GI tract (oral). Distribution: Protein-binding: 96%. Metabolism: Extensively hepatic by oxidation and glucuronidation. Excretion: Urine and faeces (as metabolites); 6-7 days (elimination half-life of the R-enantiomer).
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