It is a prescription medicine used with other antiviral medicines to treat adults with chronic (lasting a long time) hepatitis C virus (HCV): genotype 1 or 4 infection without cirrhosis or with compensated cirrhosis in combination with peginterferon alfa and ribavirin genotype 2 or 3 infection without cirrhosis or with compensated cirrhosis in combination with ribavirin
Medicince introduction including background, function, caution, etc.
Indication It is used in the treatment of chronic hepatitis C virus (HCV) infection. Side effects Tiredness, headache, nausea, diarrhea, itchy skin, difficulty sleeping. Mechanisam of Action Sofosbuvir inhibits the hepatitis C NS5B protein. Sofosbuvir appears to have a high barrier to the development of resistance. Sofosbuvir is a prodrug of the Protide type, whereby the active phosphorylated nucleotide is granted cell permeability and oral bioavailability.