Colon or rectal cancer Metastatic breast cancer Esophageal, gastric, hepatobiliary, neuroendocrine, pancreatic, ovarian, fallopian tube, peritoneal or unknown primary cancers (off-label use)
Medicince introduction including background, function, caution, etc.
Indication For the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen. May also be used in combination with docetaxel for the treatment of metastatic breast cancer in patients who have failed to respond to, or recurred or relasped during or following anthracycline-containing chemotherapy.
Side Effects Nausea and vomiting Rash & itching Abdominal pain
Mechanism Of Action FdUMP inhibits DNA synthesis by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate. 1 The active moiety of capecitabine, fluorouracil, is cell cycle phase-specific (S- phase)