Patent medicine name
Emend 125mg/80mg Capsule
Manufacturer
MSD Pharmaceuticals Pvt Ltd
Specification
Physical Form: Capsule, Quantity:3 capsule/box , Storage: Room Temperature(10-30°C)
Price
$15-20
Generic medicine name & Manufacturer
Aprecap Set, Glenmark
Specification
Physical Form: Capsule, Quantity:3 capsule/box , Storage: Room Temperature(10-30°C)
Price
$10-20
Composition
Aprepitant (125mg)
Use
Aprepitant blocks the actions of chemicals in the body that trigger nausea and vomiting.
It is used together with other medications to prevent nausea and vomiting that may be caused by chemotherapy.
Medicince introduction including background, function, caution, etc.
Indication
Aprepitant is a substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery.
SideEffects
Heartburn
Stomach pain
Diarrhea
Constipation
Mechanism Of Action
Aprepitant has been shown in animal models to inhibit emesis induced by cytotoxic chemotherapeutic agents, such as cisplatin, via central actions. Animal and human Positron Emission Tomography (PET) studies with Aprepitant have shown that it crosses the blood brain barrier and occupies brain NK1 receptors. Animal and human studies show that Aprepitant augments the antiemetic activity of the 5-HT3-receptor antagonist ondansetron and the corticosteroid ethasone and inhibits both the acute and delayed phases of cisplatin induced emesis.
Use in Other language
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